MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study.

Feriha Fatima KhidriYar Muhammad WaryahFaiza Kamran AliHina ShaikhIkram Din UjjanAli Muhammad Waryah

Published in: BMC medical genetics (2019)

This is the first case control study describing the protective role of F5:c.6665A > G against preeclampsia in any world population. In addition, the present study confirmed the association and role of MTHFR gene variations in the development of preeclampsia in Pakistani patients. Further genetic studies may be required to better understand the complex genetic mechanism of SNVs in preeclampsia related genes in pregnant women.

Keyphrases

end stage renal disease
pregnant women
early onset
genome wide
newly diagnosed
ejection fraction
chronic kidney disease
copy number
prognostic factors
peritoneal dialysis
gene expression
dna methylation
genome wide identification