Serotonin reuptake transporter deficiency promotes liver steatosis and impairs intestinal barrier function in obese mice fed a Western-style diet.

Louisa Filipe RosaEva HaasisAnnkathrin KnaussDaria GusevaStephan C Bischoff

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2023)

Our data demonstrate that SERT knockout causes weight gain, liver steatosis, and leaky gut, especially in mice fed a WSD. Therefore, SERT induction could be a novel therapeutic approach to improve metabolic diseases associated with intestinal barrier dysfunction.

Keyphrases

weight gain
high fat diet induced
insulin resistance
body mass index
birth weight
high fat diet
weight loss
physical activity
oxidative stress
electronic health record
south africa
skeletal muscle
big data
type diabetes
deep learning
machine learning