The WWOX gene in brain development and pathology.

Published in: Experimental biology and medicine (Maywood, N.J.) (2020)

WW domain-containing oxidoreductase encoded by the WWOX gene is a transcription regulator and a key player in a number of cellular and biological processes such as tumor suppression, cell proliferation, apoptosis induction, steroid metabolism, and central nervous system development. This review provides a comprehensive summary of currently known roles and discusses the importance of WWOX gene for CNS development and functioning.

Keyphrases

cell proliferation
genome wide
copy number
oxidative stress
transcription factor
blood brain barrier
dna methylation
white matter
signaling pathway
cerebral ischemia
pi k akt