IL-17 deficiency aggravates the streptozotocin-induced diabetic nephropathy through the reduction of autophagosome formation in mice.

Kyung-Hyun KimGeum-Lan HongDa-Young JungShanika KarunasagaraWon-Il JeongJu Young Jung

Published in: Molecular medicine (Cambridge, Mass.) (2021)

IL-17 deficiency aggravates of STZ-induced DN via attenuation of autophagic response. Our study demonstrated that IL-17A mediates STZ-induced renal damage and represents a potential therapeutic target in DN.

Keyphrases

type diabetes
diabetic rats
oxidative stress
diabetic nephropathy
high glucose
cell death
high fat diet
metabolic syndrome
endothelial cells
risk assessment
skeletal muscle
climate change