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Evaluation of helicene-derived 2,2'-bipyridine N- monoxide catalyst for the enantioselective propargylation of N -acylhydrazones with allenyltrichlorosilane.

Changgong XuPhillip NaderJonathan XavierBurjor CaptainNorito Takenaka
Published in: Tetrahedron (2023)
Helicene-derived 2,2'-bipyridine N -monoxide was evaluated as a Lewis base catalyst for the enantioselective propargylation of N -acylhydrazones with allenyltrichlorosilane. The helicene-derived catalyst provided moderate-to-good reactivity and enantioselectivity for a range of acylhydrazones. This study represents the first example of the catalytic asymmetric propargylation of non-activated acylhydrazones.
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