Integrative study of cell damage and cancer risk in gas station attendants.
Antônio P R FilhoMaruhen Amir Datsch SilveiraCamila B do NascimentoLuciana P G d'ArcePublished in: International journal of environmental health research (2017)
Gas station attendants are potentially exposed to carcinogenic substances. This study aimed to evaluate chronic occupational exposed gas station attendant's according to genetic parameters and its relationship with cancer predisposition. Forty gas station attendants were recruited and paired with 40 control subjects. Thousand cells from each subject were analyzed counting the number of pyknotic (PYC), karyolitic (KYL), karyorrhetic (KHC), condensed chromatin (CC), binucleated (BN), basal cells (BC), Nuclear buds (Nbud), and differentiated cells (DIFF). More 2.000 differentiated cells were analyzed counting micronucleated (MNi) and nuclear buds (NBud). We observed a statistical increase in BC and decrease in DIFF (p < 0.05). PYC, CC, KYL, MN, NBud were statistically increased (p < 0.05). All in all, our data showed elevated DNA damage, chromosomal instability, and cell cycle disturbing in our group of gas station attendants. It is a clear risk for their health in future and could be classified as a cancer predisposition.
Keyphrases
- induced apoptosis
- dna damage
- cell cycle
- room temperature
- cell cycle arrest
- oxidative stress
- healthcare
- public health
- papillary thyroid
- single cell
- cell proliferation
- transcription factor
- stem cells
- mental health
- signaling pathway
- cell death
- dna repair
- machine learning
- electronic health record
- cell therapy
- pi k akt
- ionic liquid
- artificial intelligence
- drug induced