Amylin as a potential link between type 2 diabetes and alzheimer disease.

Ivan Martinez-ValbuenaRafael Valenti-AzcarateIrene Amat-VillegasMario RiverolIrene MarcillaCarlos E de AndreaJuan Antonio Sánchez-AriasMaria Del Mar Carmona-AbellanGloria MartiMaria-Elena ErroEduardo Martínez-VilaMaria-Teresa TuñonMaría-Rosario Luquin

Published in: Annals of neurology (2019)

The presence of both tau and Aβ inclusions in pancreatic β cells, and of amylin deposits in the brain, provides new evidence of a potential overlap in the mechanisms underlying the pathogenesis of T2DM and AD. ANN NEUROL 2019;86:539-551.

Keyphrases

type diabetes
induced apoptosis
glycemic control
cell cycle arrest
white matter
human health
mild cognitive impairment
cardiovascular disease
insulin resistance
cell death
signaling pathway
multiple sclerosis
endoplasmic reticulum stress
climate change
skeletal muscle
weight loss