Polygenic Multiple Sclerosis Risk and Population-Based Childhood Brain Imaging.

Casper L de MolPhilip R JansenRyan L MuetzelMaria J Knol Hieab H H AdamsVincent W JaddoeMeike W VernooijRogier Q HintzenTonya J WhiteRinze F Neuteboom

Published in: Annals of neurology (2020)

This is the first study to show that greater genetic predisposition for MS is associated with higher global brain WM FA at an early age in the general population. Our results suggest a preadolescent time window within neurodevelopment in which MS risk variants act upon the brain. ANN NEUROL 2020;87:774-787.

Keyphrases

multiple sclerosis
white matter
resting state
mass spectrometry
functional connectivity
ms ms
cerebral ischemia
high resolution
copy number
gene expression
genome wide
young adults
neural network
fluorescence imaging