Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination.
Inge L WerkmanMarissa L DubbelaarPieter van der VliesJelkje J de Boer-BergsmaBart J L EggenWia BaronPublished in: Journal of neuroinflammation (2020)
Primary adult gmASTRs and wmASTRs are heterogeneous at the transcriptional level, differed in their support of in vitro myelination, and their pre-existing phenotype determined TLR3 agonist responses. These findings point to a role of ASTR heterogeneity in regional differences in remyelination efficiency between GM and WM lesions.