Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.

Ghmkin HassanToshiaki OharaSaid M AfifyKazuki KumonMaram H ZahraXiaoying FuMohamad Al KadiAkimasa SenoDavid S SalomonMasaharu Seno

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our result suggests that cancer-inducing microenvironment in vivo could rewire the cell signaling and metabolic pathways to convert normal stem cells into CSCs.

Keyphrases

cancer stem cells
stem cells
gene expression
cell therapy
papillary thyroid
dna methylation
single cell
squamous cell
squamous cell carcinoma
mesenchymal stem cells