Better Understanding the Timing Of Androgen Deprivation Trial Outcomes: Impacts of Prior Androgen Deprivation Therapy.
Kristian D StenslandTheresa P DevasiaMegan E V CaramChristina Hunter ChapmanAlexander ZaslavskyTodd M MorganBrent K HollenbeckJordan B SparksJennifer A BurnsVarsha VedapudiGillian M DuchesneAlexander TsodikovTed A SkolarusPublished in: JNCI cancer spectrum (2022)
The survival benefit demonstrated in the TOAD trial may be driven by patients who received ADT prior to trial entry. We provide possible explanations for this finding with implications for treatment of PSA-relapsed prostate cancer and future study planning.