Initiation of a ZAKα-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L.

Jiajia XiGoda Snieckute Abhishek AsthanaChristina GaughanSimon Bekker-Jensen Robert H Silverman

Published in: bioRxiv : the preprint server for biology (2023)

RNase L signals antiviral innate immunity from the ribosomeThe ribotoxic stress response requires the MAP3K ZAKαRNA cleavage leads to transcription of proinflammatory genesZAKα contributes to apoptosis downstream of RNase L activity.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
transcription factor
cell proliferation
signaling pathway