Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.

Sébastien J DumasElda MetaMila BorriJermaine GoveiaKaterina RohlenovaNadine V ConchinhaKim FalkenbergLaure-Anne TeuwenLaura de RooijJoanna KaluckaRongyuan ChenShawez KhanFederico TavernaWeisi LuMagdalena ParysCarla De LegherStefan VinckierTobias K KarakachLuc SchoonjansLin LinLars BolundMieke DewerchinGuy EelenTon J RabelinkXuri LiYonglun LuoPeter Carmeliet

Published in: Journal of the American Society of Nephrology : JASN (2019)

This study provides a high-resolution atlas of the renal endothelium and highlights extensive renal endothelial cell phenotypic heterogeneity, as well as a previously unrecognized role of oxidative phosphorylation in the metabolic adaptation of medullary renal endothelial cells to water deprivation.

Keyphrases

single cell
endothelial cells
rna seq
high resolution
high throughput
high glucose
mass spectrometry