ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
Natalia M MathieuPablo NakagawaConnie C GrobeJohn J RehoDaniel T BrozoskiKo-Ting LuKelsey K WackmanMcKenzie L RitterJeffrey L SegarJustin L GrobeCurt D SigmundPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
These findings suggest that in salt-sensitive hypertension, ARRB2, but not ARRB1 (β-arrestin 1), might counterbalance the canonical signaling of GPCRs.