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Highly Diastereoselective Synthesis and Application of Functionalized 2,3-Dihydrofuran Derivatives from Enynones and Bis(diazo) Compounds.

Yu ZhangGuisheng Deng
Published in: The Journal of organic chemistry (2023)
A highly efficient Ag(I)-catalyzed cascade Michael addition/cyclization of enynones with 1,3-(bis)diazo compounds has been established, providing functionalized 2,3-dihydrofuran derivatives containing a diazo group and an acetylenic bond with excellent diastereoselectivity. Transformation of the diazo group and hydration of the carbon-carbon triple bond have been performed successfully in different reaction systems.
Keyphrases
  • highly efficient
  • quantum dots
  • ionic liquid
  • structure activity relationship
  • high resolution
  • transition metal
  • crystal structure
  • simultaneous determination
  • tandem mass spectrometry