[A comparison of DNA methylation profiles of blood mononuclear cells in patients with multiple sclerosis in remission and relapse].

Ivan Kiselev O G Kulakova Olga A Baturina Marsel Rasimovich Kabilov Alexey Boyko Olga O Favorova

Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2023)

For the first time it was shown that during relapse and remission of RRMS there are differences in the DNA methylation profile that allow discrimination between these clinical stages. These data indicate the involvement of the epigenetic mechanism of DNA methylation in the activation of the pathological process in RRMS.

Keyphrases

dna methylation
genome wide
gene expression
induced apoptosis
disease activity
free survival
copy number
ulcerative colitis
electronic health record
systemic lupus erythematosus
peripheral blood
big data
cell death
endoplasmic reticulum stress
deep learning