Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment.

Per JohanssonErik G AlmqvistAnders WallinJan-Ove JohanssonUlf AndreassonKaj BlennowHenrik ZetterbergJohan Svensson

Published in: PloS one (2017)

Most cytokines and chemokines were similar in patients and controls, but CSF IL-12/23 subunit p40 concentration was decreased in patients with cognitive impairment, and correlated with markers of AD disease status. Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI.

Keyphrases

cognitive impairment
cerebrospinal fluid
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
protein kinase
patient reported
case control