Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress.

Kang WangYe WangHua WanJie WangLi HuShuainan HuangMingchen ShengJiayi WuXing HanYoujia YuPeng ChenFeng Chen

Published in: Genes & genomics (2024)

Our study revealed a functional role of ACTN2 under chronic stress, loss of ACTN2 function accelerated H9c2 hypertrophy through ERK signaling. A commercial drug, Ibudilast, was identified to reverse cell hypertrophy in vitro.

Keyphrases

signaling pathway
single cell
cell proliferation
pi k akt
drug induced
stress induced
cell therapy
emergency department
stem cells
bone marrow
adverse drug