The impact of depression and antidepressant usage on primary biliary cholangitis clinical outcomes.
Abdel-Aziz ShaheenGilaad G KaplanWagdi AlmishriIsabelle VallerandAlexandra D FrolkisScott PattenMark G SwainPublished in: PloS one (2018)
In our study, depression was not associated with poor clinical outcomes. However, using the antidepressant mirtazapine was associated with decreased mortality, decompensated cirrhosis and liver transplantation in PBC patients. These findings support further assessment of mirtazapine as a potential treatment for PBC patients.