PCSK9 and LRP5 in macrophage lipid internalization and inflammation.
Lina BadimónAureli LuqueroJavier CrespoEsther PeñaMaria Borrell-PagesPublished in: Cardiovascular research (2022)
Our results show that both LRP5 and PCSK9 participate in lipid uptake in macrophages. In the absence of LRP5, there is a reduced release of PCSK9 indicating that LRP5 also participates in the mechanism of release of soluble PCSK9. Furthermore, PCSK9 up-regulates TLR4/NFκB favouring inflammation.