Longevity of immune response after a single dose of typhoid conjugate vaccine against Salmonella Typhi among children in Hyderabad, Pakistan.
Farah Naz QamarSonia QureshiZoya HaqTahir YousafzaiIbtisam QaziSeema IrfanNajeeha IqbalZohra AmalikAneeta HotwaniQumber AliIrum FatimaNajeeb RahmanAlice S CarterJessica C SeidmanPublished in: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2024)
We observed 95.8% seroconversion after a single dose of TCV. There was a decay in anti-Vi IgG titers, and, at 4 years, approximately 75.6% remained seroconverted. There was a faster decay in children aged ≤2 years. Breakthrough infections were documented after a median 3.4 years after vaccination.