Determination of dexamethasone dose for cortisol suppression in adult common marmosets (Callithrix jacchus).

Kimberley A PhillipsMatthew LopezAdam B SalmonCorinna N RossDavid H AbbottJohn P Capitanio

Published in: Journal of medical primatology (2022)

We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.

Keyphrases

high dose
low dose
mass spectrometry
tandem mass spectrometry