Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability.

Shalom D Goldberg Tero Satomaa Olulanu Aina Olli Aitio Krista Burke Vadim Dudkin Brian Geist Onyi Irrechukwu Anna-Liisa Hänninen Annamari Heiskanen Jari Helin Jukka O Hiltunen Jacqueline Kinyamu-Akunda Donna M Klein Neeraj Kohli Titta Kotiranta Tuula Lähteenmäki Ritva Niemelä Virve Pitkänen Henna Pynnönen William Rittase Kristen Wiley Junguo Zhou Juhani Saarinen

Published in: Molecular cancer therapeutics (2024)

The optimized trastuzumab-MMAU ADC showed potent antitumor activity and was well tolerated with excellent pharmacokinetics in non-human primates, leading to a superior preclinical therapeutic window. The data supports potential utility of trastuzumab-MMAU for treatment of HER2+ tumors.

Keyphrases

epidermal growth factor receptor
metastatic breast cancer
endothelial cells
open label
induced pluripotent stem cells
big data
cancer therapy
stem cells
machine learning
anti inflammatory
diffusion weighted
combination therapy
human health
mesenchymal stem cells
artificial intelligence