Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones.

A family of chiral iodoaniline-lactate based catalysts with C 1 and C 2 symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%.