Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells.

Scott Maxwell Jun OkabeHarikrishnan KaipananickalHanah RodriguezIshant KhuranaKeith Al-HasaniBryna S M ChowEleni Pitsillou Tom C Karagiannis Karin Agnes Maria Jandeleit-Dahm Ronald C W Ma Yu Huang Juliana Chung Ngor ChanMark E CooperAssam El-Osta

Published in: Journal of the American Society of Nephrology : JASN (2024)

Set7 regulates the phenotypic endothelial-mesenchymal transition (EDMT) switch and suggest that targeting the lysine methyltransferase could protect glomerular cell injury in DKD.

Keyphrases

endothelial cells
high glucose
diabetic nephropathy
single cell
stem cells
type diabetes
bone marrow
cell therapy
vascular endothelial growth factor
cancer therapy
wound healing
mesenchymal stem cells
drug delivery