Pharmacokinetics of first-line drugs in children with tuberculosis using WHO-recommended weight band doses and formulations.

Chishala ChabalaAnna TurkovaAnneke C HesselingKevin M ZimbaMarieke van der ZalmMonica KapasaMegan PalmerMaxwell Tawanda Chirehwa Lubbe WiesnerEric WobudeyaAarti KinikarVidya MaveSyed HissarLouise ChooKristen LeBeauVeronica MulengaRobb AarnoutseDiana GibbHelen McIlleron

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Recommended weight-band based FDC doses result in lower drug exposures in children in lower weight-bands and in those ≥25kg (on adult doses). Further adjustments to current doses are needed to match current target exposures in adults. The use of ethambutol at the current WHO-recommended doses requires further evaluation.

Keyphrases

body mass index
weight loss
physical activity
young adults
weight gain
air pollution
mycobacterium tuberculosis
body weight
emergency department
hiv aids
drug induced
adverse drug
hiv infected
human immunodeficiency virus
antiretroviral therapy
clinical evaluation