Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats.

Elif Ayazoglu Demir Ahmet Menteşe Ayten Livaoglu Nihal Turkmen Alemdar Yüksel Aliyazıcıoğlu Selim Demir

Published in: Drug and chemical toxicology (2023)

The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and 3 mg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by CDDP administration ( p < 0.05). Treatments with CGA significantly alleviated these markers dose-dependently ( p < 0.05). These data reveal that CGA may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

Keyphrases

oxidative stress
diabetic rats
ischemia reperfusion injury
dna damage
induced apoptosis
gene expression
endoplasmic reticulum stress
cell cycle arrest
high glucose
dna methylation
big data
signaling pathway
machine learning
cell proliferation
anti inflammatory
deep learning