Asperidulins A and B, two new prenylxanthone derivatives from an apple-derived fungus Aspergillus nidulans KIB-HACM-01.

Two new prenylxanthone derivatives, asperidulins A ( 1 ) and B ( 2 ), along with a known emodin analogue ( 3 ) were isolated from an apple-derived fungus Aspergillus nidulans KIB-HACM-01. Their structures were elucidated by interpretation of HRMS, NMR, and comparisons of specific optical rotation. Asperidulin B ( 2 ) exhibited a moderate cytotoxicity against A549 and BEAS-2B with an IC 50 values of 13.62 ± 0.41 and 11.27 ± 0.52 μM, and methyl-averantin ( 3 ) showed moderate cytotoxicities against all six tested cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480, BEAS-2B) with IC 50 values ranging from 8.93 ± 0.56 to 35.27 ± 0.25 μM.