Sound induces analgesia through corticothalamic circuits.
Wenjie ZhouChonghuan YeHaitao WangYu MaoWeijia ZhangAn LiuChen-Ling YangTianming LiLauren HayashiWan ZhaoLin ChenYuanyuan LiuWen-Juan TaoZhi ZhangPublished in: Science (New York, N.Y.) (2022)
Sound-including music and noise-can relieve pain in humans, but the underlying neural mechanisms remain unknown. We discovered that analgesic effects of sound depended on a low (5-decibel) signal-to-noise ratio (SNR) relative to ambient noise in mice. Viral tracing, microendoscopic calcium imaging, and multitetrode recordings in freely moving mice showed that low-SNR sounds inhibited glutamatergic inputs from the auditory cortex (ACx Glu ) to the thalamic posterior (PO) and ventral posterior (VP) nuclei. Optogenetic or chemogenetic inhibition of the ACx Glu →PO and ACx Glu →VP circuits mimicked the low-SNR sound-induced analgesia in inflamed hindpaws and forepaws, respectively. Artificial activation of these two circuits abolished the sound-induced analgesia. Our study reveals the corticothalamic circuits underlying sound-promoted analgesia by deciphering the role of the auditory system in pain processing.
Keyphrases
- pain management
- air pollution
- postoperative pain
- chronic pain
- ultrasound guided
- neuropathic pain
- high glucose
- diabetic rats
- spinal cord
- working memory
- high resolution
- high fat diet induced
- endothelial cells
- drug induced
- oxidative stress
- fluorescence imaging
- mass spectrometry
- photodynamic therapy
- wild type
- anti inflammatory