Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.

Yiqing ZhouZhengao DiXiaoming LiYuanhong ShanWeichao LiHaibing ZhangYouli Xiao

Published in: Chemical communications (Cambridge, England) (2017)

CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.

Keyphrases

mass spectrometry
endothelial cells
nk cells
small molecule
high throughput
gene expression
protein protein
binding protein
induced pluripotent stem cells