Automating iPSC generation to enable autologous photoreceptor cell replacement therapy.
Laura R BohrerNicholas E StoneNathaniel K MullinAndrew P VoigtKristin R AnfinsonJessica L FickViviane LuangphakdyBradley HittleKimerly PowellGeorge F MuschlerRobert F MullinsEdwin M StoneBudd A TuckerPublished in: Journal of translational medicine (2023)
We have successfully developed a robotic iPSC generation platform and standard operating procedures for production of high-quality photoreceptor precursor cells that are compatible with current good manufacturing practices. This system will enable clinical grade production of iPSCs for autologous retinal cell replacement.
Keyphrases
- cell therapy
- replacement therapy
- single cell
- bone marrow
- induced apoptosis
- healthcare
- primary care
- induced pluripotent stem cells
- smoking cessation
- stem cells
- optical coherence tomography
- platelet rich plasma
- mesenchymal stem cells
- minimally invasive
- diabetic retinopathy
- cell cycle arrest
- cell proliferation
- endoplasmic reticulum stress