Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration.

Kristine HoleC GjestadK M HeitmannT HaslemoE MoldenS Bremer

Published in: European journal of clinical pharmacology (2016)

These findings suggest that the CYP3A4*22, CYP3A5*3, and POR*28 variant alleles are of limited importance for overall individual variability in 4βOHC levels compared to nongenetic factors.

Keyphrases

genome wide
copy number
gene expression