Surface functionalized red fluorescent dual-metallic Au/Ag nanoclusters for endoplasmic reticulum imaging.
Lifeng CuiChengyun LiBiyun ChenHong HuangQineng XiaXi LiZhangfeng ShenZhigang GeYangang WangPublished in: Mikrochimica acta (2020)
An efficient method is reported to prepare endoplasmic reticulum-targetable dual-metallic gold-silver nanoclusters, denoted as ER-Au/Ag nanoclusters (NCs), by virtue of a rationally designed molecular ligand. The prepared ER-Au/Ag NCs possesses red-emitting fluorescence with a strong emission at 622 nm and a high fluorescence quantum yield of 5.1%, which could avoid the influence of biological auto-fluorescence. Further investigation results showed that ER-Au/Ag NCs exhibited superior photostability, minimal cytotoxicity, and ER-targeting capability. Enabled by these meritorious features, ER-Au/Ag NCs have been successfully employed for long-term bioimaging of ER in living cells.Graphical abstract A sensitive non-enzymatic fluorescent glucose probe-based ZnO nanorod decorated with Au nanoparticles.
Keyphrases
- quantum dots
- sensitive detection
- endoplasmic reticulum
- energy transfer
- living cells
- single molecule
- fluorescent probe
- reduced graphene oxide
- visible light
- high resolution
- gold nanoparticles
- breast cancer cells
- blood pressure
- estrogen receptor
- adipose tissue
- metabolic syndrome
- molecular dynamics
- type diabetes
- mass spectrometry
- insulin resistance
- drug delivery
- cancer therapy