Integrating methylome and transcriptome signatures expands the molecular classification of the pituitary tumors.
Rui M Patrício da Silva-JúniorAna Carolina BuenoClarissa Silva MartinsFernanda Coelli-LacchiniJorge Guilherme Okanobo OzakiDanillo Cunha de Almeida E SilvaJunier Marrero-GutiérrezAntônio Carlos Dos SantosCarlos Garcia-PeralHélio Rubens MachadoMarcelo Volpon Dos SantosPaula Lamparelli EliasAyrton C MoreiraLeandro M ColliRicardo Z N VêncioSonir R AntoniniMargaret de CastroPublished in: The Journal of clinical endocrinology and metabolism (2022)
This large heterogenic ethnic Brazilian cohort confirms that integrated methylome and transcriptome signatures classify FPT and NFPT, which are associated with clinical presentation and tumor invasiveness. Moreover, the cluster NFPT/ACTH-secreting adenomas raises interest regarding tumor heterogeneity, supporting the challenge raised by the 2017 and 2022 WHO definition regarding the discrepancy, in rare cases, between clinical presentation and pituitary lineage markers. Finally, making our data publicly available enables further studies to validate genes/pathways involved in pituitary tumor pathogenesis and prognosis.