Integrated bioinformatics and validation reveal SOX12 as potential biomarker in colon adenocarcinoma based on an immune infiltration-related ceRNA network.

Xinyi ChenMu YangJingyao TuXiang-Lin Yuan

Published in: Journal of cancer research and clinical oncology (2023)

Through the construction of ceRNA networks and evaluation of TIICs, the study successfully established two risk score models and nomograms. These models serve as valuable tools for understanding the molecular processes and predicting the prognosis of COAD patients. Further validation of hub regulators SOX12 and H19 substantiates their potential role as key biomarkers in COAD.

Keyphrases

transcription factor
stem cells
long non coding rna
end stage renal disease
ejection fraction
squamous cell carcinoma
prognostic factors
single cell
genome wide
patient reported outcomes
bioinformatics analysis