PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin.
Antonius A de WaardTamara VerkerkMarlieke L M JongsmaKelly HoefakkerSunesh SethumadhavanCarolin GerkeSophie BlissXiangrui KongGeorge M C JanssenArnoud H de RuFrans H J ClaasArend MulderRobert TampéPeter A van VeelenAnne HaleniusRobbert M SpaapenPublished in: European journal of immunology (2021)
A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.