Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4+ Diffuse Large B-Cell Lymphoma Cells.

Aïda FalgàsVictor PallarèsUgutz UnzuetaYáiza NúñezJorge SierraAlberto GallardoLorena Alba-CastellónMaria Antonia ManguesPatricia ÁlamoAntonio VillaverdeEsther VázquezRamón ManguesIsolda Casanova

Published in: International journal of nanomedicine (2021)

T22-AUR exerts in vitro and in vivo anticancer effect on CXCR4+ DLBCL cells without off-target toxicity. Thus, T22-AUR promises to become an effective therapy for CXCR4+ DLBCL patients.

Keyphrases

diffuse large b cell lymphoma
induced apoptosis
epstein barr virus
cell cycle arrest
end stage renal disease
oxidative stress
ejection fraction
chronic kidney disease
cell migration
endoplasmic reticulum stress
peritoneal dialysis
cell death
signaling pathway
cell proliferation