Fusing the Genetic Landscape of Infantile High-Grade Gliomas.
Frank SzulzewskyPatrick J CiminoPublished in: Cancer discovery (2021)
In this issue of Cancer Discovery, Clarke and colleagues define the genetic landscape of infantile cerebral high-grade gliomas, which frequently contain alterations in the MAPK pathway, as well as recurrent gene fusions in receptor tyrosine kinases (ALK, ROS1, MET) and neurotrophic receptor kinases (NTRK1-3). Combining their multi-omic profiling data with functional preclinical and clinical studies, this large multi-institutional study provides strong rationale for future classification and molecular subtype-specific therapeutic management of infantile high-grade glioma.See related article by Clarke et al., p. 942.
Keyphrases
- high grade
- low grade
- genome wide
- copy number
- single cell
- machine learning
- papillary thyroid
- signaling pathway
- deep learning
- cell death
- dna damage
- clinical trial
- high throughput
- squamous cell carcinoma
- squamous cell
- stem cells
- current status
- gene expression
- dna methylation
- advanced non small cell lung cancer
- reactive oxygen species
- big data
- pi k akt
- single molecule
- young adults
- cerebral ischemia
- transcription factor
- lymph node metastasis
- epidermal growth factor receptor
- brain injury