Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy.

Matteo BeltramiElisa FedeleCarlo FumagalliFrancesco Mazzarotto Francesca Girolami Corrado Poggesi Raffaele Coppini Lorenzo Tofani Bruno Bertaccini Corrado Poggesi Iacopo Olivotto

Published in: Circulation. Genomic and precision medicine (2023)

MYBPC3-related HCM showed increased long-term prevalence of systolic dysfunction compared with MYH7, in spite of similar outcome. Such observations suggest different pathophysiology of clinical progression in the 2 subsets and may prove relevant for understanding of genotype-phenotype correlations in HCM.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
heart failure
risk factors
blood pressure