Quick model-based viscoelastic clot strength predictions from blood protein concentrations for cybermedical coagulation control.
Damon E GhetmiriAlessia J VenturiMitchell J CohenAmor A MenezesPublished in: Nature communications (2024)
Cybermedical systems that regulate patient clotting in real time with personalized blood product delivery will improve treatment outcomes. These systems will harness popular viscoelastic assays of clot strength such as thromboelastography (TEG), which help evaluate coagulation status in numerous conditions: major surgery (e.g., heart, vascular, hip fracture, and trauma); liver cirrhosis and transplants; COVID-19; ICU stays; sepsis; obstetrics; diabetes; and coagulopathies like hemophilia. But these measurements are time-consuming, and thus impractical for urgent care and automated coagulation control. Because protein concentrations in a blood sample can be measured in about five minutes, we develop personalized, phenomenological, quick, control-oriented models that predict TEG curve outputs from input blood protein concentrations, to facilitate treatment decisions based on TEG curves. Here, we accurately predict, experimentally validate, and mechanistically justify curves and parameters for common TEG assays (Functional Fibrinogen, Citrated Native, Platelet Mapping, and Rapid TEG), and verify results with trauma patient clotting data.
Keyphrases
- hip fracture
- high throughput
- protein protein
- intensive care unit
- case report
- type diabetes
- minimally invasive
- healthcare
- coronavirus disease
- sars cov
- cardiovascular disease
- palliative care
- amino acid
- high resolution
- binding protein
- atrial fibrillation
- small molecule
- mass spectrometry
- atomic force microscopy
- acute coronary syndrome
- trauma patients
- electronic health record
- single molecule
- surgical site infection
- acute respiratory distress syndrome
- artificial intelligence
- extracorporeal membrane oxygenation
- weight loss
- chronic pain
- skeletal muscle
- percutaneous coronary intervention
- sensitive detection
- loop mediated isothermal amplification