[11C]mHED PET follows a two-tissue compartment model in mouse myocardium with norepinephrine transporter (NET)-dependent uptake, while [18F]LMI1195 uptake is NET-independent.
Linjing MuStefanie D KrämerGeoffrey I WarnockAhmed HaiderSusan BengsGiovanni CartolanoDominic S BrämClaudia KellerRoger SchibliSimon M AmetameyPhilipp A KaufmannChristian LoewePublished in: EJNMMI research (2020)
PET with [11C]mHED but not [18F]LMI1195 provides information on NET function in the mouse heart. [11C]mHED PET is dose-independent in the mouse myocardium at < 10 nmol/kg of combined mHED and metaraminol. [11C]mHED kinetics followed serial two-tissue compartment models with K1 representing NET transport. Myocardial [11C]mHED uptake obtained from PET images may be used to assess cardiac sympathetic integrity in mouse models of cardiovascular disease.