Mouse IgG2a Isotype Therapeutic Antibodies Elicit Superior Tumor Growth Control Compared with mIgG1 or mIgE.
Natasa VukovicAina SeguésShuyu HuangMartin WaterfallAlice J A M SijtsDietmar M W ZaissPublished in: Cancer research communications (2023)
Direct comparisons of different antibody isotypes of the same specificity in cancer settings are still scarce. Here, it is shown that mIgG2a has a greater effect compared with mIgG1 and mIgE in controlling tumor growth in a therapeutic setting.