PTEN and AKT1 Variations in Childhood T-Cell Acute Lymphoblastic Leukemia
Fulya KucukcankurtYücel ErbilginSinem FirtinaOzden Hatirnaz NgZeynep KarakaşTülin Tiraje CelkanAyşegül ÜnüvarUğur ÖzbekMuge SayitogluPublished in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2019)
Targeted deep sequencing allowed us to detect both low-level variations and clonal diversity. Low-level PTEN/AKT1 variation frequency makes it harder to investigate the clinical associations of the variants. On the other hand, characterization of the PTEN/AKT signaling members is important for improving case-specific therapeutic strategies.