Mechanism of Sanhua Decoction in the Treatment of Ischemic Stroke Based on Network Pharmacology Methods and Experimental Verification.

null YingHuangShan-Shan GaoZi-Han GongWen-Jie LiXiao-Jun Gou Ji-Jia Sun Ming-Jie Sun

Published in: BioMed research international (2022)

The effective components of SHD may regulate multiple signaling pathways through IL-6, APP, AKT1, and VEGFA to reduce brain damage and inflammatory damage and exert a neuroprotective role in the treatment of IS diseases. Thus, this study provides a feasible method to study the pharmacological mechanism of traditional Chinese medicine compound prescriptions and a theoretical basis for the development of SHD into a new drug for IS treatment.

Keyphrases

signaling pathway
oxidative stress
cell proliferation
emergency department
multiple sclerosis
atrial fibrillation
combination therapy
white matter
replacement therapy
pi k akt
induced apoptosis
resting state
endoplasmic reticulum stress