Genome plasticity in Paramecium bursaria revealed by population genomics.

Yu-Hsuan ChengChien-Fu Jeff LiuYen-Hsin YuYu-Ting JhouMasahiro FujishimaIsheng Jason TsaiJun-Yi Leu

Published in: BMC biology (2020)

We report programmed DNA rearrangements in the P. bursaria macronuclear genome that allow cells to adjust gene copy number globally according to individual gene functions. Our results suggest that large-scale gene copy number variation may represent an ancient mechanism for cells to adapt to different environments.

Keyphrases

copy number
genome wide
mitochondrial dna
induced apoptosis
dna methylation
cell cycle arrest
cell death
oxidative stress
signaling pathway
single molecule
cell free