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Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform.

Peng SunZhen LiJingyun WangHui GaoXi YangSudong WuDeqiang LiuQixian Chen
Published in: Chemical communications (Cambridge, England) (2018)
A supramolecular catiomer with a metal-organic framework (MOF) motif was developed to manufacture messenger RNA (mRNA) assemblies. In contrast to the linear catiomer, the dendritic MOF catiomer appeared to markedly improve the colloidal stability of the mRNA assemblies, particularly affording substantial protection to the mRNA payloads from enzymatic degradation, eventually conducing to appreciable mRNA transfection activities at the targeted cells.
Keyphrases
  • metal organic framework
  • binding protein
  • induced apoptosis
  • magnetic resonance
  • cell cycle arrest
  • high throughput
  • hydrogen peroxide
  • cell death
  • cell proliferation
  • nucleic acid
  • drug delivery
  • pi k akt
  • contrast enhanced