Design of donor-acceptor conjugated polymers based on diketopyrrolopyrrole for NIR-II multifunctional imaging.
Mengyu CaoXuezhen MaChang WangWentao ZouFang WangBing YuHailin CongYou-Qing ShenPublished in: Journal of materials chemistry. B (2024)
Diketopyrrolopyrrole (DPP) is an excellent photosensitizer and photothermal agent with the advantages of good planarity, strong electron affinity, high electron mobility, easy purification, easy structural modification and high molar absorption coefficient. It is regarded as one of the ideal choices for the design and synthesis of efficient organic photovoltaic materials. Therefore, two kinds of donor-acceptor (D-A) conjugated polymers were designed and synthesized with DPP as the acceptor, and their optical properties and applications in the near-infrared region were studied. The quantum yield (QY) of PBDT-DPP is 0.46%, and the highest temperature reached within 10 minutes after irradiation with a 660 nm laser is 60 °C. Another polymer, EDOT-DPP, has a QY of 0.48%, and its semiconductor polymer nanoparticle aqueous solution can reach 60 °C within 12 minutes under laser irradiation, achieving photothermal treatment of nude mice tumors. Both polymer NPs have good biocompatibility and promising applications in bioimaging and photothermal therapy.
Keyphrases
- photodynamic therapy
- solar cells
- fluorescence imaging
- aqueous solution
- energy transfer
- drug delivery
- cancer therapy
- high resolution
- high speed
- quantum dots
- molecular dynamics
- drug release
- computed tomography
- type diabetes
- metabolic syndrome
- magnetic resonance imaging
- high fat diet induced
- combination therapy
- room temperature
- magnetic resonance
- smoking cessation
- capillary electrophoresis