Neuropsychiatric symptoms and ApoE genotype in older adults without dementia: a cross-sectional study.

Florindo Stella Marcos Vasconcelos Pais Júlia Cunha Loureiro Augusto Magno Tranquezi Cordeiro Leda Leme Talib Orestes Vicente Forlenza

Published in: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (2024)

Our analyses showed associations between NPS and the presence of the ApoE ε4 allele in two NPI-C domains, despite the sample size. Furthermore, compared to noncarriers, the presence of the ApoE ε4 correlated positively with appetite/eating disorders and negatively with aberrant motor disturbance domain. Examination of the amnestic MCI group displayed significant, although weak, associations. Therefore, ε4 carriers exhibited higher depression scores according to the HAM-D scale compared to ε4 noncarriers. Conversely, ε4 noncarriers had higher scores in the aggression domain of the NPI-C than ε4 carriers.

Keyphrases

mild cognitive impairment
cognitive decline
physical activity
high fat diet
sleep quality
depressive symptoms
weight loss
risk factors
adipose tissue
type diabetes
body weight
cognitive impairment