Systematic assessment of multi-echo dynamic susceptibility contrast MRI using a digital reference object.

Multi-echo acquisitions were more robust than single-echo, essentially decoupling both repetition time and flip angle from rCBV accuracy. Multi-echo acquisitions obviate the need for preload dosing, although leakage correction to remove residual T 2 ∗ leakage effects remains compulsory for high rCBV accuracy.