Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner.
Dipti ThakkarShalini PaliwalBhushan DharmadhikariSiyu GuanLillian LiuShreya KarNikhil K TulsianJoshua J GruberLeah DiMascioKonrad H PaszkiewiczPiers J IngramJerome D Boyd-KirkupPublished in: Journal for immunotherapy of cancer (2022)
In conclusion, we have shown that VISTA-induced immune suppression can be reversed by blockade of the functional C-C' loop region of VISTA with a first-in-class rationally targeted and non-depleting IgG4 isotype anti-VISTA antibody, HMBD-002. This antibody represents a highly promising novel therapy in the VISTA-suppressed ICT non-responder population.